Biochemistry Ph.D.
Students must meet the Graduate School's requirements for the Ph.D. degree. The Ph.D. degree in Biochemistry requires the completion of significant, original independent research and preparation of a thesis for submission to the Graduate School. In most cases it is expected that the Ph.D. degree be completed within 4-6 years of admission to the graduate program.
Credits: Graduate credits are earned for courses numbered 800-999. A minimum of two semesters of Doctoral Research (BCHM 999) is required. Many Ph.D. candidates enroll in BCHM 851-852 during their first year of study, unless the diagnostic examinations indicate a sufficient undergraduate preparation in general biochemistry.
Diagnostic Exams: Three separate examinations in organic chemistry, physical chemistry, and biochemistry will be administered to all incoming graduate students during the orientation week, which is the week before school begins in fall semester. These tests consist of multiple choice questions designed to test a broad knowledge of the three subject areas. The purpose of these exams is to determine courses to be taken by each student. The table below summarizes scores needed to exempt students from certain courses, and options available to the student if a passing score is not achieved. This may be achieved by either passing the diagnostic exams administered in the week before classes, or by achieving a B or better in Organic Chemistry (CHEM 651, 653), Physical Biochemistry (BCHM 850) and achieving a B+ or better in Biochemistry 851& 852. Passing scores for the diagnostics are shown below.
Students should consult with the graduate coordinator or thesis advisor to plan a remedial course of action since this requirement must be satisfied to remain in the graduate program.
PRELIMINARY EXAMINATION REQUIREMENTS FOR Ph.D. STUDENTS
Test |
Score Percentile |
Result/Course of Action |
Organic Chemistry ACS Test |
‹30 |
|
|
›30 |
Pass |
Physica Chemistry ACS Test |
‹40 |
Take BCHM 850 for physical chemistry and earn a grade of B or better |
|
›30 |
Pass |
Biochemistry ACS Test |
‹60 |
Take BCHM 851/852 and earn an average grade of B or better; |
|
›60 and ‹80 |
Take BCHM 851 and earn a grade of B or better |
|
›80 |
Pass |
Identification of thesis project:
Guidance Committee: During the second semester, and after selecting a thesis project and an advisor, the student, in conjunction with the advisor, will choose a Guidance Committee. This committee consists of five faculty members: the advisor (as chairperson), two other members of the Biochemistry faculty, and up to two faculty members from outside departments. However, only three members of the Guidance Committee are required for the 2nd year exam. The committee will meet soon after selection of a thesis project to determine the student's curriculum. Courses required by the Guidance Committee must be taken for credit and completed with a passing grade (at least a B-). Courses recommended by the committee may be audited or taken for credit, but in either case the student is expected to be familiar with the subject matter of these courses. The Guidance Committee will meet each semester thereafter to assess the student's academic and research progress. The Supervisory Committee Nomination Form needs to be completed and submitted to the Graduate School by the end of the first year.
Preliminary (or Qualifying) Examinations: Students must take the following two exams before being advanced to candidacy: The Preliminary Exams consist of the Second Year Exam and Third Year Exam.
a. Second-Year Exam -Qualifying Exam- Part 1
During the spring of the second year, the student will prepare and defend a written research proposal on a topic that is outside the thesis topic. To begin this process, the student will discuss possible topics with committee members. The student will then submit a one-page pre-proposal in February to the Guidance Committee. For the Second-Year Exam, the Guidance Committee consists of a minimum of three members from the Biochemistry Department including the thesis advisor; up to two other members can be added to this committee. This pre-proposal will briefly outline the topic, identify the problem that will be the focus, and state the means proposed to address the problem. The committee will meet and evaluate the pre-proposal based on its general appropriateness. The student will then prepare an eight- to 10-page proposal research plan only (single spaced, one-inch margins, 12-point type). References should be included but will not count in the page tally.
The finished proposal should be submitted to committee members at least two weeks in advance and no later than August before the start of the third year. An announcement should be made to all faculty. The oral presentation will be given to all Biochemistry faculty and the Guidance Committee. Following the oral presentation, the Guidance Committee and student will convene in a separate room and the Guidance Committee will conduct an oral defense of the proposal for one half of the time, for an equivalent time of a minimum of one hour. The second part of the exam (an equivalent time of a minimum of one hour), the student will be asked a series of questions in which the student is expected to demonstrate knowledge of biochemistry and molecular biology that ranges beyond the research project. The student may pass this exam outright or conditionally. Conditions may include revision, expansion of the proposal, or additional coursework. A student who fails the Second-Year Exam may be allowed one attempt to retake the exam within six months, or be asked to withdraw from the Ph.D. pathway. The outcome of the exam needs to be recorded with the Graduate Coordinator and the Doctoral Candidacy form completed (first part).
b. Third-Year Exam -Qualifying exam- Part II
The Guidance Committee for the Third-Year Exam consists of five faculty members: the advisor (as chairperson), two other members of the Biochemistry faculty, and two faculty members from outside departments. This is an oral examination of one to several hours in length. It should occur by the end of the third year. The student should submit to each committee member a written description of the thesis problem, summary of research progress to date, and outline of research goals yet to be attained. This document should be several pages in length and should be submitted at least two weeks before the scheduled date of the exam. A short opening oral research presentation is followed by questions. This exam should focus primarily upon the student's research and the general area of his or her interests. For instance, a student working on gene cloning should understand all aspects of DNA biochemistry, structure and function, as well as gene expression as represented in part by content of advanced courses taken by the student. The exam is used to assess the student's ability to plan and conduct research, to think critically and creatively about questions in the student's area of interest, and to be aware of current and recent research literature in these areas. If the proposal has depth, the committee's questions will probably remain focused on the proposed research. If the proposal is wanting, the questions may range further. This exam can be taken only after successful completion of the Second-Year Exam and completion of most coursework. Students may pass this exam outright or conditionally. Conditions may include revision or expansion of the proposal. A student who fails the Third-Year Exam may be allowed one attempt to retake the exam, or be asked to withdraw from the Ph.D. pathway. After passing the Qualifying Examination, the doctoral student is advanced to candidacy and a Doctoral Committee is normally selected.
The Doctoral Candidacy form needs to be completed and returned to the Graduate School.
Doctoral Committee: The Doctoral Committee is composed of the faculty advisor (as chairperson), two other faculty members in the Biochemistry Department, and two faculty from other departments. In most cases, the Guidance Committee will constitute the Doctoral Committee. The Doctoral Committee evaluates the dissertation and administers the final examination. The Doctoral Committee will meet annually to assess the progress toward completion of the Ph.D. requirements.
Written Thesis: The student is required to prepare a written doctoral dissertation for submission to the Doctoral Committee. The dissertation must represent significant and original research written in a clear, comprehensible style. A copy of the complete thesis must be made available to the committee at least two weeks before the date of the final examination. (Consult the Thesis and Dissertation Manual provided by the Graduate School for details on preparing the manuscript.) Publication of the dissertation by University Microfilms is required. All costs associated with the preparation and publication of the thesis are the responsibility of the student.
Final Defense: An oral examination of the doctoral dissertation consists of two parts: an oral presentation of the research that is open to the public, and an oral defense of the dissertation conducted by the Doctoral Committee. Final approval of the doctoral dissertation will be determined by a majority vote of the Doctoral Committee. The Final Examination must be completed by the date listed in the Graduate School calendar. Three copies of the approved dissertation, ready for binding, will be submitted to the Graduate School Office at least two weeks before commencement. The student will also provide copies (softbound) to members of the Doctoral Committee who want copies. Graduate students may request an exception to departmental policy by completing a written petition to the graduate faculty of the Department of Biochemistry and Molecular Biology. The Intent-to- Graduate form needs to be completed and sent to the Graduate School.
